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Technology Description and Features
OPAL library
- Fully synthetic, human scFv library with six diversified CDRs
- CDR diversification by degenerate oligonucleotides, reflecting naturally occurring amino acids at each position
- Single framework design for easy sequence manipulation, uniformly high expression level and stability
- Validated on 100s of antigens: proteins, peptides, and small molecules
- In active use by >20 labs and companies
OPAL-S Library
- Fully synthetic, human scFv library with improved CDR design
- Non-combinatorial CDR diversity designed to emulate naturally produced CDR sequences
- Higher humanness of CDR sequences compared to conventionally designed libraries
- Better developability without undesirable PTM motifs
- Validated by NGS and panning against multiple antigens
Panning
- Utilization of two highly functional libraries for successful antibody isolation
- Parellel panning on same targets using multiple panning strategies maximizes the clonal diversity
- Panning on passively adsorbed or biotinylated antigens, whole cells expressing membrane protein antigen, etc.
- Antigen design based on target structure, desired epitope, and antigenicity