iMab : Technology for Targeting Cytosolic Proteins

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Technology Description and Features

MoA
● Cellular internalization
● Cytosolic localization by endosomal escape
● Specific binding to the targeted cytosolic
● protein involved in PPI
● PPI interference
● Drug effects

Lead
● Ras targeting iMab : cannot be further disclosed (under patent preparation)

Indication
● Cancers
● Particularly colon/pancreatic cancers with ~60% K-Ras mutants

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