Implementation of Web-based High-Throughput Screening Calculation System

Practical Business

Authors Seong-ho Cho, Inhee Kim, Jiwon Kong, Daesan Kim, Namhoon Kwon, Robert E. Burrier, Sunghoon Kim
Journal Journal of KIISE
Vol.(no.) 46(3)
Pages 260-267
Year 20190315
DOI 10.5626/JOK.2019.46.3.260
Attach 07(261-268) DBV18-09application/pdf

Abstract

이 논문에서는 nanoluciferase 시스템의 생화학 반응 과정에서 도출한 데이터를 고속으로 계산하고 신약 후보물질을 신속히 찾아내도록 보조하는 웹 기반 초고속 계산-탐색 시스템(HTSCS) 개발 결과물을 설명한다. 이 시스템에서는 단일 농도(Single-Dose)와 다중 농도(Multi-Dose)로 세포 실험체에 후보물질을 투여(in-vitro)한 대량의 실험 데이터를 계산하여, 차트 및 그래프 정보로 나타낸다. 따라서 HTSCS 시스템으로 신약 후보물질 발견에 필요한 시간과 노력을 줄일 수 있다.

In this paper, we describe the development of a web-based HTSCS (High Throughput Screening Calculation System), which is the process for assisting high-speed screening and calculation of drug candidates based on biochemical reactions from Nanoluciferase system. This system calculates and displays large amounts of experimental data with single-dose and multi-dose concentration in-vitro cell experiments through charts and graphs. Therefore, we can utilize the HTSCS to save time and effort required for drug screening.

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