Publications

XLS
Category Subject Vol.(No.) Pages Authors Journal Year
Integration Core Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer 8(8) 1347-1354 Ji Ye Jung, Eun Young Kim, Arum Kim, Joon Chang, Nam Hoon Kwon, Youngji Moon, Eun Joo Kang, Jun Sik Sung, Hyunbo Shim, Sunghoon Kim, Yoon Soo Chang Journal of Cancer 20170512
Integration Core Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cell inpress Sang Bum Kim Journal of Cell Biology 20170508
Integration Core Serine 207 phosphorylated Lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma. inpress Suliman Boulos, Min Chul Park, Marian Zeibak, Shen Yun Foo, Yoon Kyung Jeon, Young Tae Kim, Alex Motzik, Sagi Tshori, Tamar Hamburger, Sunghoon Kim, Hovav Nechushtan, Ehud Razin Oncotarget 20170425
Drug Screening A chemical biology route to site-specific authentic protein modifications. 354(6312) 623-626 Aerin Yang, Sura Ha, Jihye Ahn, Rira Kim, Sungyoon Kim, Younghoon Lee, Jaehoon Kim, Dieter Söll, Hee-Yoon Lee, Hee-Sung Park Science 20161104
Integration Core Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity 17(11) 1252-1262 Lee EY, Lee HC, Kim HK, Jang SY, Park SJ, Kim YH, Kim JH, Hwang J, Kim JH, Kim TH, Arif A, Kim SY, Choi YK, Lee C, Lee CH, Jung JU, Fox PL, Kim S, Lee JS, Kim MH Nature Immunology 20161101
Integration Core Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection. 2 16191 Ahn YH, Park S, Choi JJ, Park BK, Rhee KH, Kang E, Ahn S, Lee CH, Lee JS, Inn KS, Cho ML, Park SH, Park K, Park HJ, Lee JH, Park JW, Kwon NH, Shim H, Han BW, Kim P, Lee JY, Jeon Y, Huh JW, Jin M, Kim S Nature Microbiology 20161017
Integration Core O-GlcNAcylation of orphan nuclear receptor ERRγ promotes hepatic gluconeogenesis. 65(10) 2835-2848 Jagannath Misra, Don-Kyu Kim, Yoon Seok Jung, Han Byeol Kim, Yong-Hoon Kim, Eun-Kyung Yoo, Byung Gyu Kim, Sunghoon Kim, In-Kyu Lee, Robert A. Harris, Jeong-Sun Kim, Chul-Ho Lee, Jin Won Cho, Hueng-Sik Choi Diabetes 20161001
Integration Core Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling. 16(9) 1510–1517 Mee-Sup Yoon, Kook Son, Edwin Arauz, Jung Min Han, Sunghoon Kim, Jie Chen Cell Reports 20160809
Integration Core AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt/β-catenin signaling. 76(15) 4559-4568 Min Kyu Yum, Jong-Seol Kang, Al-Eum Lee, Young-Woo Jo, Ji Yun Seo, Hyun-A Kim, Yoon-Young Kim, Jinwoo Seong, Eun Byul Lee, Ji-Hoon Kim, Jung Min Han, Sunghoon Kim, Young-Yun Kong Cancer Research 20160801
Integration Core Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor Suppressive Interaction with Smurf2. 76(11) 3422-3436 Dae Gyu Kim, Jin Young Lee, Ji-Hyun Lee, Ha Yeon Cho, Beom Sik Kang, Song-Yee Jang, Myung Hee Kim, Min Guo, Jung Min Han, Seong-Jin Kim, Sunghoon Kim Cancer Research 20160701
Integration Core Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase(LRS)-targeted mTORC1 inhibitor. 26(13) 3038-3041 Suyoung Yoon, Jong Hyun Kim, Ina Yoon, Changhoon Kim, Sung-Eun Kim, Yura Koh, Seung Jae Jeong, Jiyoun Lee, Sunghoon Kim, Jeewoo Lee Bioorganic & Medicinal Chemistry Letters 20160701
Integration Core Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration. 48(4) 1553-1560 Seo Hee Nam, Minkyung Kang, Jihye Ryu, Hye-Jin Kim, Doyeun Kim,Dae Gyu Kim, Nam Hoon Kwon, Sunghoon Kim, Jung Weon Lee International Journal of Oncology 20160401
Integration Core Novel morphological and genetic analysis of cancer cells in a 3D microenvironment identifies STAT3 as a regulator of tumor permeability barrier function. 76(5) 1044-1054 Min Chul park, Hyobin Jeong, Sung Hwa Son, Younha Kim, Daeyoung Han, Peter C. Goughnour, Taehee Kang, Nam Hoon Kwon, Hyo Eun Moon, Sun Ha Paek, Daehee Hwang, Ho Jun Seol, Do-Hyun Nam, Sunghoon Kim Cancer Research 20160301
Integration Core PharmDB-K: integrated bio-pharmacological network database for 1 Traditional Korean Medicine. 10(11) e0142624 Ji-Hyun Lee, Kyoung Mii Park, Dong-Jin Han, Nam Young Bang, Do-Hee Kim, Hyeongjin Na, Semi Lim, Tae Bum Kim, Dae Gyu Kim, Hyun-Jung Kim, Yeonseok Chung, Sang Hyun Sung, Young-Joon Surh, Sunghoon Kim, Byung Woo Han Plos One 20151110
Integration Core Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-Homology Domains 290(49) 29313-29328 Ha Yeon Cho, Seo Jin Maeng, Hyo Je Cho, Yoon Seo Choi, Jeong Min Chung, Sangmin Lee, Hoi Kyoung Kim, Jong Hyun Kim, Chi-Yong Eom, Yeon-Gil Kim, Min Guo, Hyun Suk Jung, Beom Sik Kang, Sunghoon Kim Journal of Biological Chemistry 20151015
Integration Core Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer. 112(40) 12492-12497 Hansoo Park, Sung-Yup Cho, Hyerim Kim, Deukchae Na, Jee Yun Han, Jeesoo Chae, Changho Park, Ok-Kyoung Park, Seoyeon Min, Jinjoo Kang, Boram Choi, Jimin Min, Jee Young Kwon, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Edison T. Liu, Jong-Il Kim, Sunghoon Kim, Han-Kwang Yang, Charles Lee Proceedings of the National Academy of Sciences of the United States of America 20151006
Integration Core Screening of quinoline, 1,2-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis. 13(26) 9381-9387 Hanumantharayappa Bharathkumar, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Taehee Kang, H.K. Keerthy, Julian E. Fuchs, Nam Hoon Kwon, Andreas Bender, Sunghoon Kim, Basappa, Kanchugarakoppal S. Rangappa Organic and Biomolecular Chemistry 20150928
Integration Core Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels. 6(25) 21655-21674 Nam SH, Kim D, Lee MS, Lee D, Kwak TK, Kang M, Ryu J, Kim HJ, Song HE, Choi J, Lee GH, Kim SY, Park SH, Kim DG, Kwon NH, Kim TY, Thiery JP, Kim S, Lee JW Oncotarget 20150828
Integration Core A novel in vitro permeability assay using three-dimensional cell culture system. 205 93-100 Jong Bong Lee, Sung Hwa Son, Min Chul Park, Tae Hwan Kim, Min Gi Kim, Sun Dong Yoo, Sunghoon Kim Journal of Biotechnology 20150710
Integration Core The BioMart Community Portal: an innovative alternative to large, centralized data repositories. 43(W1) W589-598 Byung Woo Han, Ji-Hyun Lee, Sunghoon Kim 외 99인 Nucleic Acids Research 20150701
Integration Core Tpl2 induces castration resistant prostate cancer progression and metastasis. 136(9) 2065-2077 Hye Won Lee, Hyun Jung Cho, Se Jeong Lee, Hye Jin Song, Hee Jin Cho, Min Chul Park, Ho Jun Seol, Jung-Il Lee, Sunghoon Kim, Hyun Moo Lee, Han Yong Choi, Do-Hyun Nam, Kyeung Min Joo International Journal of Cancer 20150501
Integration Core 1H, 13C and 15N resonance assignment of WHEP domains of human glutamyl-prolyl tRNA synthetase. 9(1) 25-30 ChinHo Shin, Geum-Sook Hwang, Hee-Chul Ahn, Sunghoon Kim, Key-Sun Kim Biomolecular NMR Assignments 20150401
Drug Design Liposome-Based Engineering of Cells To Package Hydrophobic Compounds in Membrane Vesicles for Tumor Penetration. 15(5) 2938-2944 Junsung Lee, Jiyoung Kim, Moonkyoung Jeong, Hyoungjin Lee, Unbyeol Goh, Hyaeyeong Kim, Byungji Kim, Ji-Ho Park Nano Letters 20150331
Integration Core Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. 6 6402 Pengfei Fang, Xue Yu, Seung Jae Jeong, Adam Mirando, Kaige Chen, Xin Chen, Sunghoon Kim, Christopher S. Francklyn, Min Guo Nature Communications 20150331
Integration Core Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer. 2015 1-14 Ji-Hyun Lee, Sungyong You, Do Young Hyeon, Byeongsoo Kang, Hyerim Kim, Kyoung Mii Park, Byungwoo Han, Daehee Hwang, Sunghoon Kim Database 20150329
Integration Core miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18. 36(6) 9724 Seunghee Lee, Kyung-Rok Yu, Young-Sil Ryu, Young Sun Oh, In-Sun Hong, Hyung-Sik Kim, Jin Young Lee, Sunghoon Kim, Kwang-Won Seo, Kyung-Sun Kang American Aging Association 20141204
Integration Core A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells. 6(6) 1402-1414 Dong-Ki Choi1, Jeomil Bae1, Seung-Min Shin, Ju-Yeon Shin, Sunghoon Kim, Yong-Sung Kim MAbs 20141102
Integration Core Structure of the ArgRS–GlnRS–AIMP1 complex and its implications for mammalian translation. 111(42) 15084-15089 Yaoyao Fu, Youngran Kim, Kyeong Sik Jin, Hyun Sook Kim, Jong Hyun Kim, DongMing Wang, Minyoung Park, Chang Hwa Jo, Nam Hoon Kwon, Doyeun Kim, Myung Hee Kim, Young Ho Jeon, Kwang Yeon Hwang, Sunghoon Kim, Yunje Cho Proceedings of the National Academy of Sciences of the United States of America 20141021
Integration Core AIMP1/p43 negatively regulates adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma. 127(20) 4483-4493 Jong Hyun Kim, Jung Ho Lee, Min Chul Park, Ina Yoon, Kibom Kim, Minji Lee, Heung-Sik Choi, Sunghoon Kim, Jung Min Han Journal of Cell Science 20141015
Integration Core Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation against oxidative stresses. 127(19) 4234-4245 Jin Young Lee, Dae Gyu Kim, Byung-Gyu Kim, Won Suk Yang, Jeena Hong, Taehee Kang, Young Sun Oh, Kyung Rok Kim, Byung Woo Han, ByungJoon Hwang, BeomSik Kang, Mi-Sun Kang, Myung-Hee Kim, Nam Hoon Kwon, Sunghoon Kim Journal of Cell Science 20141001
Integration Core Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR. 588(17) 2851-2858 Hye Young Cho, Ameeq Ul Mushtaq, Jin Young Lee, Dae Gyu Kim, Min Sook Seok, Minseok Jang, Byung-Woo Han, Sunghoon Kim, Young Ho Jeon Febs letters 20140825
Integration Core Translational validation of personalized treatment strategy based on genetic characteristics of glioblastoma. 9(8) e103327 Young Taek Oh, Hee Jin Cho, Jinkuk Kim, Ji-Hyun Lee, Kyoohyoung Rho, Yun-Jee Seo, Yeon-Sook Choi, Hye Jin Jung, Hyeon Suk Song, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Yeup Yoon, Sunghoon Kim, Do-Hyun Nam1, Kyeung Min Joo Plos One 20140801
Target ID The crystal structure of arginyl-tRNA synthetase from Homo sapiens. 588(14) 2328-2334 Hyun Sook Kim, So Young Cha, Chang Hwa Jo, Ahreum Han, Kwang Yeon Hwang FEBS Letters 20140727
Integration Core Degradation of AIMP1/p43 induced by hepatitis C virus E2 leads to upregulation of TGF-β signaling and increase in surface expression of gp96. 9(5) e96302 Min Soo Kim, Sunghoon Kim, Heejoon Myung Plos One 20140509
Integration Core A novel adenoviral vector-mediated mouse model of Charcot-Marie-Tooth type 2D (CMT2D). 45(2) 121-128 Ah Jung Seo, Youn Ho Shin, Seo Jin Lee, Doyeun Kim, Byung Sun Park, Sunghoon Kim, Kyu Ha Choi, Na Young Jeong, Chan Park, Ji-Yeon Jang, Youngbuhm Huh, Junyang Jung Journal of Molecular Histology 20140401
Integration Core A novel adenoviral vector-mediated mouse model of Charcot-Marie-Tooth type 2D (CMT2D). 45(2) 121-128 Ah Jung Seo, Youn Ho Shin, Seo Jin Lee, Doyeun Kim, Byung Sun Park, Sunghoon Kim, Kyu Ha Choi, Na Young Jeong, Chan Park, Ji-Yeon Jang, Youngbuhm Huh, Junyang Jung Mol Histol 20140401
Target ID The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. 5 2958 Jungwon Hwang, Hyun-Woo Suh, Young Ho Jeon, Eunha Hwang, Loi T. Nguyen, Jeonghun Yeom, Seung-Goo Lee, Cheolju Lee, Kyung Jin Kim, Beom Sik Kang, Jin-Ok Jeong, Tae-Kwang Oh, Inpyo Choi, Jie-Oh Lee, Myung Hee Kim Nature Communications 20140106
Integration Core Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction. 10(1) 29-34 Dae Gyu Kim, Jin Young Lee, Nam Hoon Kwon, Pengfei Fang, Qian Zhang, Jing Wang, Nicolas L Young, Min Guo, Hye Young Cho, Ameeq Ul Mushtaq, Young Ho Jeon, Jin Woo Choi, Jung Min Han, Ho Woong Kang, Jae Eun Joo, Youn Hur, Wonyoung Kang, Heekyoung Yang, Do-Hyun Nam, Mi-Sook Lee, Jung Weon Lee, Eun-Sook Kim, Aree Moon, Kibom Kim, Doyeun Kim, Eun Joo Kang, Youngji Moon, Kyung Hee Rhee, Byung Woo Han, Jee Sun Yang, Gyoonhee Han, Won Suk Yang, Cheolju Lee, Ming-Wei Wang, Sunghoon Kim Nature Chemical Biology 20140101
Drug Design The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. 4 3000 Dong Ju Son, Sandeep Kumar, Wakako Takabe, Chan Woo Kim, Chih-Wen Ni, Noah Alberts-Grill, In-Hwan Jang, Sangok Kim, Wankyu Kim, Sang Won Kang, Andrew H. Baker, Jai Woong Seo, Katherine W. Ferrara, Hanjoong Jo Nature Communications 20131218
Integration Core Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma. 11(11) 1375-1386 Hye Won Lee, Kyeung Min Joo, Joung Eun Lim, Hyun Jung Cho, Hee Jin Cho, Min Chul Park, Ho Jun Seol, Seong Il Seo, Jung-Il Lee, Sunghoon Kim, Byong Chang Jeong, Do-Hyun Nam Molecular Cancer Research 20131101
Integration Core Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. 81(10) 1840-1846 Kyung Rok Kim, Sang Ho Park, Hyoun Sook Kim, Kyung Hee Rhee, Byung-Gyu Kim, Dae Gyu Kim, Mi Seul Park, Hyun-Jung Kim, Sunghoon Kim, Byung Woo Han Proteins 20131001
Target ID Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. 81(10) 1840-1846 Kyung Rok Kim, Sang Ho Park, Hyoun Sook Kim, Kyung Hee Rhee, Byung-Gyu Kim, Dae Gyu Kim, Mi Seul Park, Hyun-Jung Kim, Sunghoon Kim, Byung Woo Han Proteins 20131001
Integration Core Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases. 2014(344) 119-44 Jong Hyun Kim, Jung Min Han, Sunghoon Kim Topics in Current Chemistry 20130927
Integration Core Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumor regression. 454(3) 411-416 Hee Sook Lee, Dae Gyu Kim, Young Sun Oh, Nam Hoon Kwon, Jin Young Lee, Doyeun Kim, Song-Hwa Park, Jong-Hwan Song, Sunkyung lee, Jung Min Han, Bum-Joon Park, Jongkook Lee, Sunghoon Kim Biochemical Journal 20130915
Integration Core Identification of upstream regulators for prognostic expression signature genes in colorectal cancer. 7 86 Taejeong Bae, Kyoohyoung Rho, Jin Woo Choi, Katsuhisa Horimoto, Wankyu Kim, Sunghoon Kim BMC Systems Biology 20130904
Integration Core Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. D69 2136-2145 Jonghyeon Son, Eun Hye Lee, Minyoung Park, Jong Hyun Kim, Junsoo Kim, Sunghoon Kim, Young Ho Jeon, Kwang Yeon Hwang Acta Crystallographica Section D 20130724
Target ID Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. 110(30) E2829-37 Jungwon Hwang, Byoung Sik Kim, Song Yee Jang, Jong Gyu Lim, Dong-Ju You, Hyun Suk Jung, Tae-Kwang Oh, Jie-Oh Lee, Sang Ho Choi, Myung Hee Kim Proceedings of the National Academy of Sciences of the United States of America 20130723
Integration Core Association of aminoacyl-tRNA synthetases with cancer. 2014(344) 207-45 Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim Topics in Current Chemistry 20130702
Integration Core Multiple reaction monitoring of multiple low-abundance transcription factors in whole lung cancer cell lysates 12(6) 2582-2596 Jun Seok Kim, Youngju Lee, Min Young Lee, Jihye Shin, Jung Min Han, Eun Gyeong Yang, Myeong-Hee Yu, Sunghoon Kim, Daehee Hwang, Cheolju Lee Journal of Proteome Research 20130415
Integration Core Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ. 3(1) 260-273 Kyeung Min Joo, Jinkuk Kim, Juyoun Jin, Misuk Kim, Ho Jun Seol, Johongir Muradov, Heekyoung Yang, Yoon-La Choi, Woong-Yang Park, Doo-Sik Kong, Jung-Il Lee, Young-Hyeh Ko,3,5 Hyun Goo Woo, Jeongwu Lee, Sunghoon Kim, Do-Hyun Nam Cell Reports 20130131
Integration Core Structural switch of lysyl-tRNA synthetase between translation and transcription. 49(1) 30-42 Yifat Ofir-Birin, Pengfei Fang, Steven P. Bennett, Hui-Min Zhang, Jing Wang, Inbal Rachmin, Ryan Shapiro, Jing Song, Arie Dagan, Jorge Pozo, Sunghoon Kim, Alan G. Marshall, Paul Schimmel, Xiang-Lei Yang, Hovav Nechushtan, Ehud Razin, Min Guo Molecular Cell 20130110
Integration Core AIMP3/p18 controls translational initiation by mediating the delivery of charged initiator tRNA to initiation complex. 423(4) 475-481 Taehee Kang, Nam Hoon Kwon, Jin Young Lee, Min Chul Park, Eunji Kang, Hyo Hyun Kim, Taek Jin Kang, Sunghoon Kim Journal of Molecular Biology 20121102
Integration Core Cancer association study of aminoacyl-tRNA synthetase signaling network in glioblastoma. 7(8) e40960 Yong-Wan Kim, ChangHyuk Kwon, Juinn-Lin Liu, Se Hoon Kim, Sunghoon Kim PLos One 20120831
Integration Core CDA: Combinatorial drug discovery using transcriptional response modules. 7(8) 1-10 Ji-Hyun Lee, Dae Gyu Kim, Tae Jeong Bae, Kyoohyoung Rho, Ji-Tae Kim, Jong-Jun Lee, Yeongjun Jang, Byung Cheol Kim, Kyoung Mii Park, Sunghoon Kim PLoS One 20120808
Target ID The diagnostic utility of the GNAS mutation in patients with fibrous dysplasia: meta-analysis of 168 sporadic cases. 43(8) 1234-1242 Seung Eun Lee, Eun Hee Lee, Heejung Park, Ji-Youn Sung, Hyoun Wook Lee, So Young Kang, Sungwook Seo, Byung Heon Kim, Hyojin Lee, An Na Seo, Geunghwan Ahn, Yoon-La Choi Human Pathology 20120801
Drug Screening Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA. 4(4) 258-261 Seong Ok Kim, Hyerim Yoon, Seong Oak Park, Miju Lee, Jae-Sun Shin, Kyoung-Seok Ryu, Jie-Oh Lee, Yeon-soo Seo, Hyun Suk Jung, Byong-Seok Choi Journal of Molecular Cell Biology 20120709
Integration Core Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43. 125 4620–4629 Hyuk-Sang Kwon, Min Chul Park, Dae Gyu Kim, Ki Won Jo, Young Woo Park, Jung Min Han, Sunghoon Kim Journal of Cell Science 20120705
Integration Core Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. 6(1) e80 Hee Sook Lee, Taejeong Bae, Ji-Hyun Lee, Dae Gyu Kim, Young Sun Oh, Yeongjun Jang, Ji-Tea Kim, Jong-Jun Lee, Alessio Innocenti, Claudiu T Supuran, Luonan Chen, Kyoohyoung Rho, Sunghoon Kim BMC Systems Biology 20120702
Integration Core Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration. 26(10) 4142-4159 Dae Gyu Kim, Jin Woo Choi, Jin Young Lee, Hyerim Kim, Young Sun Oh, Jung Weon Lee, Yu Kyung Tak, Joon Myong Song, Razin Ehud, Seok-Hyun Yun, Sunghoon Kim The FASEB Journal 20120702
Target ID Expression profiling of more than 3500 proteins of MSS-type colorectal cancer by stable isotope labeling and mass spectrometry. 75(10) 3050-3062 Un-Beam Kang, Jeonghun Yeom, Hye-Jung Kim, Hoguen Kim, Cheolju Lee Journal of Proteomics 20120606
Integration Core Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer. 4(3) 164-173 Jin Woo Choi, Jeong-Won Lee, Jun Ki Kim, Hye-Kyung Jeon, Jung-Joo Choi, Dae Gyu Kim, young-Gie Kim, Do-Hyun Nam, Hong Joong Kim, Seok Hyun Yun, Sunghoon Kim Journal of Molecular Cell Biology 20120604
Integration Core AIMP1 deficiency enhances airway hyperreactivity in mice via increased TH2 immune responses. 143(3) 256–265 Hye-Jin Hong, Eugene Kim, Mi Young Jung, Sunghoon Kim, Tae Sung Kim Clinical Immunology 20120601
Target ID Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing. 51(6) 590-597 Yeonjoo Jung, Pora Kim, Yeonhwa Jung, Juhee Keum, Soon-Nam Kim, Yong Soo Choi, In-Gu Do, Jinseon Lee, So-Jung Choi, Sujin Kim, Jong-Eun Lee, Jhingook Kim, Sanghyuk Lee, Jaesang Kim Genes Chromosomes Cancer 20120601
Target ID Mutated IDH1 is a favorable prognostic factor for type 2 gliomatosis cerebri. 22(3) 307-317 Mi Jung Kwon, Sung Tae Kim, Mi Jeong Kwon, Doo-Sik Kong, Dageun Lee, Sanghui Park, So Young Kang, Ji-Young Song, Do-Hyun Nam, Yukinari Kato, Yoon-La Choi, Yeon-Lim Suh Brain Pathology 20120501
Disease Modeling Oxidative stress-induced biomarkers for stem cell-based chemical screening. 54 Suppl S42-49 Se-Ran Yanga, Irfan Rahmand, James E. Troskoe, Kyung-Sun Kang Preventive Medicine 20120501
Integration Core Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. 8(6) 547-554 Mathew Sajish, Quansheng Zhou, Shuji Kishi, Delgado M Valdez Jr, Mili Kapoor, Min Guo, Sunhee Lee, Sunghoon Kim, Xiang-Lei Yang, Paul Schimmel Nature Chemical Biology 20120415
Integration Core Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. 149(2) 410-424 Jung Min Han, Seung Jae Jeong, Min Chul Park, Gyuyoup Kim, Nam Hoon Kwon, Hoi Kyoung Kim, Sang Hoon Ha, Sung Ho Ryu, Sunghoon Kim Cell 20120413
Drug Screening Asymmetric mode of Ca²⁺-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling. 20(4) 654-666 Paul R. Elliott, Andrew F. Irvine, Hyun Suk Jung, Kaeko Tozawa, Martyna W. Pastok, Remigio Picone, Sandip K. Badyal, Jaswir Basran, Philip S. Rudland, Roger Barraclough, Lu-Yun Lian, Clive R. Bagshaw, Marina Kriajevska, Igor L. Barsukov Structure 20120404
Target ID A prognostic model for lymph node-negative breast cancer patients based on the integration of proliferation and immunity. 132(2) 499-509 Ensel Oh, Yoon-La Choi, Taesung Park, Seungyeoun Lee, Seok Jin Nam, Young Kee Shin Breast Cancer Research and Treatment 20120401
Integration Core Chemical modulators working at pharmacological interface of target proteins. 20(6) 1893-1901 Young Ho Jeon, Jin Young Lee, Sunghoon Kim Bioorganic & Medicinal Chemistry 20120315
Target ID Chemical modulators working at pharmacological interface of target proteins. 20(6) 1893-1901 Young Ho Jeon, Jin Young Lee, Sunghoon Kim Bioorganic & Medicinal Chemistry 20120315
Integration Core Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. 109(11) E640-647 Min Chul Park, Taehee Kang, Da Jin, Jung Min Han, Sang Bum Kim, Yoon Chung Park, Kiwon Cho, Young Woo Park, Weiwei He, Xiang-Lei Yang, Paul Schimmel, Sunghoon Kim Proceedings of the National Academy of Sciences of the United States of America 20120313
Target ID Crystal structure of the NurA-dAMP-Mn2+ complex. 40(5) 2258-2570 Jina Chae, Young Chang Kim, Yunje Cho Nucleic Acids Research 20120301
Target ID Clinical significance of CD151 overexpression in subtypes of invasive breast cancer. 106(5) 923-930 Kwon MJ, Park S, Choi JY, Oh E, Kim YJ, Park YH, Cho EY, Kwon MJ, Nam SJ, Im YH, Shin YK, Choi YL British Journal of Cancer 20120228
Disease Modeling Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition. 1823(2) 514-523 Mi-Sook Lee, Hwang-Phill Kim, Tae-You Kim, Jung Weon Lee Biochimica et Biophysica Acta 20120201
Disease Modeling Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in CCl(4) -treated mice. 279(4) 625-35 Minkyung Kang, Soo-Jin Jeong, Sook Young Park, Hyo Jeong Lee, Hyun Jeong Kim, Ki Hun Park, Sang-Kyu Ye, Sung-Hoon Kim, Jung Weon Lee FEBS Journal 20120201
Disease Modeling JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation. 314(2) 198-205 Hyeonjung Kim, Oisun Jung, Minkyung Kang, Mi-Sook Lee, Doyoung Jeong, Jihye Ryu, Youra Ko, Yoon-Ju Choi, Jung Weon Lee Cancer Letters 20120128
Target ID Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. 26(1) 219-228 Jeong Soon Par, Woo Cheol Lee, Kwon Joo Yeo, Kyoung-Seok Ryu, Malika Kumarasiri, Dusan Hesek, Mijoon Lee, Shahriar Mobashery, Jung Hyun Song, Seung Il Kim, Je Chul Lee, Chaejoon Cheong, Young Ho Jeon, Hye-Yeon Kim FASEB Journal 20120101
Target ID Structural and functional characterization of Helicobacter pylori DsbG. 585(24) 3862-3867 Ji Young Yoon, Jieun Kim, Sang Jae Lee, Hyoun Sook Kim, Ha Na Im, Hye-Jin Yoon, Kyoung Hoon Kim, Soon-Jong Kim, Byung Woo Han, Se Won Suh FEBS Lett 20111215
Target ID Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents. 21(24) 7509-7512 Dao Thi Kim Oanh, Hoang Van Hai, Sang Ho Park, Hyun-Jung Kim, Byung-Woo Han, Hyung-Sook Kim, Jin-Tae Hong, Sang-Bae Han, Van Thi My Hue, Nguyen-Hai Nam Bioorganic & Medicinal Chemistry Letters 20111215
Integration Core Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3. 108(49) 19635-19640 Nam Hoon Kwon, Taehee Kang, Jin Young Lee, Hyo Hyun Kim, Hye Rim Kim, Jeena Hong, Young Sun Oh, Jung Min Han, Min Jeong Ku, Sang Yeol Lee, Sunghoon Kim Proceedings of the National Academy of Sciences of the United States of America 20111206
Target ID Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. 31(23) 4775-4788 Nam-Shik Kim, Hyoung-Tai Kim, Min-Chul Kwon, Suk-Won Choi, Yoon-Young Kim, Ki-Jun Yoon, Bon-Kyoung Koo, Myung-Phil Kong, Juhee Shin, Yunje Cho, Young-Yun Kong Molecular and Cellular Biology 20111201
Disease Modeling Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. 31(23) 4775-4788 Nam-Shik Kim, Hyoung-Tai Kim, Min-Chul Kwon, Suk-Won Choi, Yoon-Young Kim, Ki-Jun Yoon, Bon-Kyoung Koo, Myung-Phil Kong, Juhee Shin, Yunje Cho, Young-Yun Kong Molecular and Cellular Biology 20111201
Disease Modeling Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. 6(11) e28068 Ji-Won Jung, Sang-Bum Park, Soo-Jin Lee, Min-Soo Seo, James E. Trosko, Kyung-Sun Kang PLoS One 20111123
Target ID Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein. 18(12) 1336-1344 Hye-Ra Lee, Won-Chan Choi, Stacy Lee, Jungwon Hwang, Eunha Hwang, Koushik Guchhait, Juergen Haas, Zsolt Toth, Young Ho Jeon, Tae-Kwang Oh, Myung Hee Kim, Jae U Jung Nature Structural & Molecular Biology 20111106
Integration Core Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells. 5(11) e1398 Manuel Castro de Moura, Francesc Miro, Jung Min Han, Sunghoon Kim, Antonio Celada, Lluis Ribas de Pouplana PLoS Neglected Tropical Disease 20111105
Target ID Crystal structure of Arabidopsis thaliana 12-oxophytodienoate reductase isoform 3 in complex with 8-iso prostaglandin A(1). 79(11) 3236-41 Byung Woo Han, Thomas E. Malone, Do Jin Kim, Craig A. Bingman, Hyun-Jung Kim, Brian G. Fox, George N. Phillips Jr Proteins 20111101
Drug Screening Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells. 36(11) 2083-2090 Hyoseok Yi, Seong Jin Lee, Jiyeong Lee, Chang-Seon Myung, Woo-Kyu Park, Hee-Jong Lim, Ge Hyeong Lee, Jae Yang Kong, Heeyeong Cho Neurochem Res 20111101
Drug Design One target, different effects: a comparison of distinct therapeutic antibodies against the same targets. 43(10) 539-549 Hyunbo Shim Experimental and Molecular Medicine 20111031
Target ID Crystal structure of Mycobacterium tuberculosis Rv3168: a putative aminoglycoside antibiotics resistance enzyme. 79(10) 2983-2987 Sangwoo Kim, Chi My Thi Nguyen, Eun-Jung Kim, Kyung-Jin Kim Proteins 20111001
Target ID Overexpression, crystallization and preliminary X-ray crystallographic analysis of the C-terminal cytosolic domain of mouse anoctamin 1. 67(Pt 10) 1250-1252 Sang Ho Park, Ho Kyung Chung, Do Jin Kim, Mi Ra Han, Mi Seul Park, Uhtaek Oh, Hyun-Jung Kim, Byung Woo Han Acta Crystallogr Sect F Struct Biol Cryst Commun 20111001
Drug Screening Programming magnetic anisotropy in polymeric microactuators. 10(10) 747-52 Jiyun Kim, Su Eun Chung, Sung-Eun Choi, Howon Lee, Junhoi Kim, Sunghoon Kwon Nature Materials 20111001
Disease Modeling Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality. 1813(10) 1777-1783 Han Jeong Lim, Yoon Jeon, Chang Hwan Jeon, Jong Hyun Kim, Ho Lee Biochimica et Biophysica Acta 20111001
Integration Core Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping. 11(10) 708-718 Sunghoon Kim, Sungyong You, Daehee Hwang Nature Reviews Cancer 20110928
Integration Core Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells. 134(1) 73–81 Eugene Kim, Hye-Jin Hong, Daeho Cho, Jung Min Han, Sunghoon Kim, Tae Sung Kim Immunology 20110901
Drug Screening In situ fabrication and actuation of polymer magnetic microstructures. 20(1) 785-787 Su Eun Chung, Jiyun Kim, Sung-Eun Choi, Lily Nari Kim, Sunghoon Kwon JMEMS Letters 20110801
Target ID Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50. 25(10) 1091-1104 Hye Seong Lim, Jin Seok Kim, Young Bong Park, Gwang Hyeon Gwon, Yunje Cho Genes & Development 20110515
Integration Core Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells. 31(10) 2111-2121 Irit Carmi-Levy, Alex Motzik, Yifat Ofir-Birin, Zohar Yagil, Christopher Maolin Yang, David Michael Kemeny, Jung Min Han, Sunghoon Kim, Gillian Kay, Hovav Nechushtan, Ryo Suzuki, Juan Rivera, Ehud Razin Molecular and Cellular Biology 20110501
Target ID Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs. 108(17) 6921-6926 Kyungmin Kim, Bulat I. Khayrutdinov, Chung-Kyung Lee, Hae-Kap Cheong, Sung Wook Kang, Hyejin Park, Sangho Lee, Yang-Gyun Kim, JunGoo Jee, Alexander Rich, Kyeong Kyu Kim, Young Ho Jeon Proceedings of the National Academy of Sciences of the United States of America 20110426
Integration Core Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis. 7(3) e1001351 Jin Woo Choi, Dae Gyu Kim, Al-Eum Lee, Hye Rim Kim, Jin Young Lee, Nam Hoon Kwon, Young Kee Shin, Soon-Kyung Hwang, Seung-Hee Chang, Myung-Haing Cho, Yoon-La Choi, Jhingook Kim, Seung Hyun Oh, Bora Kim, Soo-Youl Kim, Hyo-Sung Jeon, Jae Yong Park, Hyunseok Peter Kang, Bum Joon Park, Jung Min Han, Sunghoon Kim PLoS Genetics 20110301
Integration Core GARNET-gene set analysis with exploration of annotation relations. 12(Suppl 1) S25 Kyoohyoung Rho, Bumjin Kim, Youngjun Jang, Sanghyun Lee, Taejeong Bae, Jihae Seo, Chaehwa Seo, Jihyun Lee, Hyunjung Kang, Ungsik Yu, Sunghoon Kim, Sanghyuk Lee, Wan Kyu Kim, Sanghyuk Lee BMC Bioinformatics 20110215
Drug Screening Polymer based chemical delivery to multichannel capillary patterned cells. 11(4) 605-608 Sung Hoon Lee, Austen James Heinz, Sung-Eun Choi, Wook Park, Sunghoon Kwon Lab on a Chip 20110211
Drug Screening Active guidance of 3D microstructures. 6(23) 2668-2672 Sung Hoon Lee, Sung-Eun Choi, Austen James Heinz, Wook Park, Sangkwon Han, Yoonseok Jung, Sunghoon Kwon Small 20101206
Target ID DDS, 4,4′-diaminodiphenylsulfone, extends organismic lifespan. 107(45) 19326-19331 Sung Chun Cho, Moon Cheol Park, Bhumsuk Keam, Jung Min Choi, Yunje Cho, Soonsil Hyun, Sang Chul Park, Junho Lee Proceedings of the National Academy of Sciences of the United States of America 20101109
Integration Core Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. 9(5) 810-822 Young Sun Oh, Dae Gyu Kim, Gyuyoup Kim, Eung-Chil Choi, Brian K. Kennedy, Yousin Suh, Bum Joon Park, Sunghoon Kim Aging Cell 20101009
Integration Core Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation. 397(1) 100-105 Gyuyoup Kim, Jung Min Han, Sunghoon Kim Biochemical and Biophysical Research Communications 20100618
Integration Core Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus. 15(4) 358–366 Sang Gyu Park, Ho Seon Park, In-Kyong Jeong, Young Min Cho, Hong Kyu Lee, Young-Sun Kang, Sunghoon Kim, Kyong Soo Park Biomarkers 20100601
Integration Core Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad for cellular homeostasis. 62(4) 296-302 Sang Gyu Park, Eung-Chil Choi, Sunghoon Kim International Union of Biochemistry and Molecular Biology 20100401
Integration Core Identification of gp96 as a novel target for treatment of autoimmune disease in mice. 5(3) e9792 Jung Min Han, Nam Hoon Kwon, Jin Young Lee, Seung Jae Jeong, Hee Jung Jung, Hyung Rae Kim, Zihai Li, Sunghoon Kim Plos One 20100323
Integration Core Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43). 287(2) 157-164 Jung Min Han, Heejoon Myung, Sunghoon Kim Cancer Letter 20100128
Integration Core A theoretical model for p53 dynamics: identifying optimal therapeutic strategy for its activation and stabilization. 8(22) 3707-3716 Do-Hyun Kim, Kyoohyoung Rho, Sunghoon Kim Cell Cycle 20091115
Integration Core MSC p43 required for axonal development in motor neurons. 106(37) 15944-15949 Xiaodong Zhu, Yang Liu, Yanqing Yin, Aiyun Shao, Bo Zhang, Sunghoon Kim, Jiawei Zhou Proceedings of the National Academy of Sciences of the United States of America 20090915
Integration Core Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. 30(9) 1638-1644 Jin Woo Choi, Jung Yeon Um, Joydeb Kumar Kundu, Young-Joon Surh, Sunghoon Kim Carcinogenesis 20090901
Integration Core AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2. 122(15) 2710-2715 Jin Woo Choi, Dae Gyu Kim, Min Chul Park, Jung Yeon Um, Jung Min Han, Sang Gyu Park, Eung-Chil Choi, Sunghoon Kim Journal of Cell Science 20090801
Integration Core LysRS serves as a key signaling molecule in the immune response by regulating gene expression. 34(5) 603-611 Nurit Yannay-Cohen, Irit Carmi-Levy,Gillian Kay, Christopher Maolin Yang, Jung Min Han, D. Michael Kemeny, Sunghoon Kim, Hovav Nechushtan, Ehud Razin Molecular Cell 20090612
Integration Core 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. 44(1) 239-250 Farhanullah, Taehee Kang, Eun-Jung Yoon, Eun-Chil Choi, Sunghoon Kim, Jeewoo Lee European Journal of Medicinal Chemistry 2009
Integration Core The physiological role of lysyl tRNA synthetase in the immune system. 103 1-27 Hovav Nechushtan, Sunghoon Kim, Gillian Kay, Ehud Razin Advances in Immunology 2009
Integration Core Aminoacyl tRNA synthetases and their connections to disease. 105(32) 11043-11049 Sang Gyu Park, Paul Schimmel, Sunghoon Kim Proceedings of the National Academy of Sciences of the United States of America 20080812
Integration Core AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. 105(32) 11206-11211 Jung Min Han, Bum-Joon Park, Sang Gyu Park, Young Sun Oh, So Jung Choi, Sang Won Lee, Soon-Kyung Hwang, Seung-Hee Chang, Myung-Haing Cho, Sunghoon Kim Proceedings of the National Academy of Sciences of the United States of America 20080812
Integration Core AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. 371(3) 395-400 Yeon Sook Lee, Jung Min Han, Sung Hwa Son, Jin Woo Choi, Eun Ju Jeon, Suk-Chul Bae, Young In Park, Sunghoon Kim Biochemical and Biophysical Research Communications 20080704
Integration Core Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM. 283(20) 14032-14040 Kyung-Jin Kim, Min Chul Park, So Jung Choi, Young Sun Oh, Eung-Chil Choi, Hyo Je Cho, Myung Hee Kim, Soo-Hyun Kim, Dong Wook Kim, Sunghoon Kim, Beom Sik Kang The Journal of Biological Chemistry 20080516
Integration Core AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability. 180(5) 2894-2902 Kim, E., Kim, S. H., Kim, S., Cho, D., and Kim, T. S. The Journal of Immunology 20080301
Integration Core Aminoacyl-tRNA synthetase-interacting multi-functional protein 1/p43: an emerging therapeutic protein working at systems level. 3(8) 945-957 Sang Won Lee, Gyuyoup Kim, Sunghoon Kim Expert Opinion on Drug Discovery 2008
Integration Core Discovery of novel indazole-linked triazoles as antifungal agents. 17(12) 3486-3490 Joon Seok Park, Kyung A Yu, Tae Hee Kang, Sunghoon Kim, Young-Ger Suh Bioorganic & Medicinal Chemistry Letters 20070615
Integration Core Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases. 170(6) 2042-2054 Jung Min Han, Sang Gyu Park, Bei Liu, Bum-Joon Park, Jin Young Kim, Cheng He Jin, Yeong Wook Song, Zihai Li, Sunghoon Kim American Journal of Pathology 20070601
Integration Core Hierarchical network between the components of the multi-tRNA synthetase complex: implications for complex formation. 281(50) 38663-38667 Jung Min Han, Min Ji Lee, Sang Gyu Park, Sun Hee Lee, Ehud Razin, Eung-Chil Choi, Sunghoon Kim The Journal of Biological Chemistry 20061215
Integration Core Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors. 14(21) 7154-7159 Farhanullah, Su Yeon Kim, Eun-Jeong Yoon, Eung-Chil Choi, Sunghoon Kim, Taehee Kang, Farhana Samrin, Sadhna Purie, Jeewoo Lee Bioorganic & Medical Chemistry 20061101
Integration Core Hormonal activity of AIMP1/p43 for glucose homeostasis. 103(40) 14913-14918 Sang Gyu Park, Young Sun Kang, Jin Young Kim, Chang Seok Lee, Young Gyu Ko, Woo Je Lee, Ki-Up Lee, Young Il Yeom, Sunghoon Kim Proceedings of the National Academy of Sciences of the United States of America 20061003
Integration Core Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors. 16(18) 4898-4907 Su Yeon Kim, Yeon-Sook Lee, Taehee Kang, Sunghoon Kimb, Jeewoo Lee Bioorganic & Medicinal Chemistry Letters 20060915
Integration Core Do aminoacyl-tRNA synthetases have biological functions other than in protein biosynthesis? 58(9) 556-558 Sang Gyu Park, Sunghoon Kim IUBMB Life 20060901
Integration Core AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability. 66(14) 6913-6918 Bum-Joon Park, Young Sun Oh, Seung Yong Park, So Jung Choi, Cornelia Rudolph, Brigitte Schlegelberger, Sunghoon Kim Cancer Research 20060715
Integration Core Antitumor activity of the novel human cytokine AIMP1 in an in vivo tumor model. 21(2) 213-217 Yeon-Sook Lee, Jung Min Han, Taehee Kang, Young In Park, Hwan Mook Kim, Sunghoon Kim Molecules and Cells 20060430
Integration Core Structural separation of different extracellular activities in aminoacyl-tRNA synthetase-interacting multi-functional protein, p43/AIMP1. 342(1) 113-118 Jung Min Han, Sang Gyu Park, Yeonsook Lee, Sunghoon Kim Biochemical and Biophysical Research Communications 20060331
Integration Core The novel cytokine p43 induces IL-12 production in macrophages via NF-kappaB activation, leading to enhanced IFN-gamma production in CD4+ T cells. 176(1) 256-264 Eugene Kim, Seung Hyun Kim, Sunghoon Kim, Tae Sung Kim The Journal of Immunology 2006
Integration Core Multi-functional proteins in tumorigenesis: Aminoacyl-tRNA synthetases and translational components. 3(4) 233-247 Sang Won Lee, Young Sun Kang, Sunghoon Kim Current Proteomics 2006
Integration Core Aminoacyl-tRNA synthetase-interacting multi-functional protein, p43, is imported to endothelial cells via lipid rafts. 96(6) 1286-1295 Jae-Sung Yi, Ji-Yeon Lee, Sung-Gil Chi, Ji-Hyun Kim, Sang Gyu Park, Sunghoon Kim, Young-Gyu Ko Journal of Cellular Biochemistry 20051215
Integration Core Inactivation of organellar glutamyl- and seryl-tRNA synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants. 280(44) 37098-37106 Yu-Kyung Kim, Jae-Yong Lee, Hye Sun Cho, Sang Sook Lee, Hyun Jung Ha, Sunghoon Kim, Doil Choi, Hyun-Sook Pai The Journal of Biological Chemistry 20051104
Integration Core Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers. 30(10) 569-574 Sang Gyu Park, Karla L. Ewalt, Sunghoon Kim Trends in Biochemical Sciences 20051030
Integration Core Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. 25(35) 7968-7978 Han Seok Ko, Rainer von Coelln, Sathya R. Sriram, Seong Who Kim, Kenny K. K. Chung, Olga Pletnikova, Juan Troncoso, Brett Johnson, Roya Saffary, Eyleen L. Goh, Hongjun Song, Bum-Joon Park, Min Jung Kim, Sunghoon Kim, Valina L. Dawson, Ted M. Dawson The Journal of Neuroscience 20050831
Integration Core Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. 15(14) 3389-3393 Sung Eun Kim, Su Yeon Kim, Sunghoon Kim, Taehee Kang, Jeewoo Lee Bioorganic & Medicinal Chemistry Letters 20050715
Integration Core Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response. 102(18) 6356-6361 Sang Gyu Park, Hye Jin Kim, You Hong Min, Eung-Chil Choi, Young Kee Shin, Bum-Joon Park, Sang Won Lee, Sunghoon Kim Proceedings of the National Academy of Sciences of the United States of America 20050503
Integration Core The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. 166(2) 387-398 Sang Gyu Park, Hyosook Shin, Young Kee Shin, Yeonsook Lee, Eung-Chil Choi, Bum-Joon Park, Sunghoon Kim American Journal of Pathology 20050201
Integration Core The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. 120(2) 209-221 Bum-Joon Park, Jin Wook Kang, Sang Won Lee, So-Jung Choi, Young Kee Shin, Young Ha Ahn, Yun Hee Choi, Dongho Choi, Kwang Soo Lee, Sunghoon Kim Cell 20050128
Integration Core Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. 119(2) 195-208 Prabha Sampath, Barsanjit Mazumder, Vasudevan Seshadri, Carri A. Gerber, Laurent Chavatte, Michael Kinter, Shu M. Ting, J. David Dignam, Sunghoon Kim, Donna M. Driscoll, Paul L. Fox Cell 20041015
Integration Core Nuclear localization of aminoacyl-tRNA synthetases using single-cell capillary electrophoresis laser-induced fluorescence analysis. 76(16) 4741-4746 Nilhan Gunasekera, Sang Won Lee, Sunghoon Kim, Karin Musier-Forsyth, Edgar Arriaga Analytical Chemistry 20040815
Integration Core Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents. 14(15) 3881-3883 Sun-Young Jang, Young Hwan Ha,Seung Whan Ko, Wonku Lee, Jongkook Lee, Sunghoon Kim, Yong Woo Kim, Won Koo Lee, Hyun-Joon Ha Bioorganic & Medicinal Chemistry Letters 20040804
Integration Core Aminoacyl-tRNA synthetase complexes: beyond translation. 117(17) 3725-3734 Sang Won Lee, Byeong Hoon Cho, Sang Gyu Park, Sunghoon Kim Journal of Cell Science 20040801
Integration Core Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly. 78(14) 7553-7564 Rabih Halwani, Shan Cen, Hassan Javanbakht, Jenan Saadatmand, Sunghoon Kim, Kiyotaka Shiba, Lawrence Kleiman Journal of Virology 20040701
Integration Core Effect of solvent on the surface of protein chip plate. 37(2) 76-79 June Won Hyun, Mi Young Yun, S. M. An, S. J. Noh, Young-Duk Huh, Heonyong Park, Y. S. Song, Jaeho Pyee, K. R. Kim, S. Kim Journal of the Korean institute of surface engineering 20040402
Integration Core A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase. 11(2) 149-156 Yoshiaki Kise, Sang Won Lee, Sang Gyu Park, Shuya Fukai, Toru Sengoku, Ryohei Ishii, Shigeyuki Yokoyama, Sunghoon Kim, Osamu Nureki Nature Structural & Molecular Biology 20040201
Integration Core Structure of the N-terminal extension of human aspartyl-tRNA synthetase: implications for its biological function. 35(11) 1548-1557 Hae-Kap Cheong, Jin-Young Park , Eun-Hee Kim , Chulhyun Lee , Sunghoon Kim , Youngsoo Kim , Byong-Seok Choi d , Chaejoon Cheong The International Journal of Biochemistry & Cell Biology 20031101
Integration Core Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. 34(3) 330-336 Min Jung Kim, Bum-Joon Park, Young-Sun Kang, Hyoung June Kim, Jae-Hyun Park, Jung Woo Kang, Sang Won Lee, Jung Min Han, Han-Woong Lee, Sunghoon Kim Nature Genetics 20030701
Integration Core Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43. 542(1-3) 119-124 Hee-Chul Ahn, Sunghoon Kim, Bong-Jin Lee FEBS Letters 20030508
Integration Core Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics. 61(4) 278-288 Kim S, Lee SW, Choi E-C, Choi SY Applied Microbiology and Biotechnology 20030501
Integration Core Molecular network and functional implications of macromolecular tRNA synthetase complex. 303(4) 985-993 Jung Min Han, Jin Young Kim, Sunghoon Kim Biochemical and Biophysical Research Communications 20030418
Integration Core In vitro development of resistance to a novel fluoroquinolone, DW286, in methicillin-resistant Staphylococcus aureus clinical isolates. 51(4) 1011-1016 Mi-Jeong Kim, Hee-Jeong Yun, Jin-Wook Kang, Sunghoon Kim, Jin-Hwan Kwak, Eung-Chil Choi Journal of Antimicrobial Chemotherapy 20030401
Integration Core Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital. 51(3) 619-623 Hee-Jeong Yun, Sang Won Lee, Gyu Man Yoon, Su Yeon Kim, Sooyoung Choi, Yeong Seon Lee, Sunghoon Kim Journal of Antimicrobial Chemotherapy 20030301
Integration Core Protein immobilization on plasma-polymerized ethylenediamine-coated glass slides. 313(1) 41-45 Jinmo Kim, Heonyong Park, Donggeun Jung, Sunghoon Kim Analytical Biochemistry 20030201
Integration Core A novel sol-gel method to produce the poly-L-lysine coated plate as a platform for protein chips. 24(4) 1-2 June Won Hyun, Shi Yong Kim, Sanghee Lee, Heonyong Park, Jaeho Pyee, Sunghoon Kim Bulletin of The Korean Chemical Society 20030110
Integration Core Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs. 76(24) 13111-13115 Shan Cen, Hassan Javanbakht, Sunghoon Kim, Kiyotaka Shiba, Rebecca Craven, Alan Rein, Karla Ewalt,Paul Schimmel, Karin Musier-Forsyth, Lawrence Kleiman Journal of Virology 20021201
Integration Core Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43. 20(4) 148-153 Heonyong Park, Sang Gyu Park, Junghee Kim, Young-Gyu Ko, Sunghoon Kim Cytokine 20021124
Integration Core Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. 277(47) 45243-45248 Sang Gyu Park, Young-Sun Kang, Young Ha Ahn, Soon Hee Lee, Kwang-Rok Kim, Kyu-Won Kim, Gou Young Koh, Young-Gyu Ko, Sunghoon Kim The Journal of Biological Chemistry 20021122
Integration Core Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. 277(46) 44448-44454 Jooyoung Jung, Soon-Youl Lee, Sun Wook Hwang, Hawon Cho, Jieun Shin, Young-Sun Kang, Sunghoon Kim, Uhtaek Oh The Journal of Biological Chemistry 20021115
Integration Core Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. 22(22) 7721-7730 Hee-Sae Park, Ssang-Goo Cho, Chang Kyun Kim, Hyun Sub Hwang, Kyung Tae Noh, Mi-Sung Kim, Sung-Ho Huh, Myung Jin Kim, Kanghyun Ryoo, Eun Kyung Kim, Woo Jin Kang, Jae-Seon Lee, Jeong-Sun Seo,Young-Gyu Ko, Sunghoon Kim, Eui-Ju Choi Molecular and Cellular Biology 20021101
Integration Core Protein adsorption on the nickel-coated glass slide for protein chips. 23(12) 1-5 June Won Hyun, Shi Yong Kim, Sanghee Lee, Heonyong Park, Jaeho Pyee, Sunghoon Kim Bulletin of The Korean Chemical Society 20020731
Integration Core p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. 99(12) 7912-7916 Jin Young Kim, Young-Sun Kang, Joong-Won Lee, Hyoung June Kim, Young Ha Ahn, Heonyong Park, Young-Gyu Ko, Sunghoon Kim. Proceedings of the National Academy of Sciences of the United States of America 20020611
Integration Core Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. 277(10) 8388-8394 Sun Young Chang, Sang Gyu Park, Sunghoon Kim, Chang-Yuil Kang The Journal of Biological Chemistry 20020308
Integration Core Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. 291(1) 158-164 Jong Sang Lee, Sang Gyu Park, Heonyong Park, Wongi Seol, Sangwon Lee, Sunghoon Kim Biochemistry & Biophysical Research Communications 20020215
Integration Core Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways. 71(2) 223-230 Heonyong Park, Sang Gyu Park, Taeho Kim, Gyuyoup Kim, Young-Gyu Ko, Sunghoon Kim Journal of Leukocyte Biology 20020201
Integration Core Novel regulatory interactions and activities of mammalian tRNA synthetases. 2(9) 1304-1310 Young-Gyu Ko, Heunyong Park, Sunghoon Kim Proteomics 2002
Integration Core Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. 276(42) 39103-39106 Young-Gyu Ko,Young-Sun Kang, Heunyong Park, Wongi Seol, Jinyoung Kim,Taeho Kim, Hee-Sae Park, Eui-Ju Choi, Sunghoon Kim The Journal of Biological Chemistry 20011019
Integration Core A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes. 276(25) 23028-23033 Young-Gyu Ko, Heunyong Park, Taeho Kim, Joong-Won Lee, Sang Gyu Park, Wongi Seol, Jee Eun Kim, Won-Ha Lee, Se-Hwa Kim, Jeong-Euy Park, Sunghoon Kim The Journal of Biological Chemistry 20010622
Integration Core Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. 11(8) 965-968 Jeewoo Lee, Sanguk Kang, Suyeon Kim, Sungeun Kim, Yeongjoon Jo, Sunghoon Kim Bioorganic & Medicinal Chemistry Letters 20010423
Integration Core Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. 11(8) 961-964 Jeewoo Lee, Sanguk Kang, Suyeon Kim, Sungeun Kim Meekyoung Kang, Yeongjoon Jo, Sunghoon Kim Bioorganic & Medicinal Chemistry Letters 20010423
Integration Core Msx1 gene overexpression induces G1 phase cell arrest in human ovarian cancer cell line OVCAR3. 281(5) 1234-1240 Jinhee Park, Kyungsook Park, Sunghoon Kim, and Je-Ho Lee Biochemistry & Biophysical Research Communications 20010301
Integration Core Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. 276(8) 6030-6036 Young-gyu Ko, Enu-kyoung Kim, Taeho Kim, Heonyong Park, Hee-Sae Park, Eui-ju Choi, Sunghoon Kim The Journal of Biological Chemistry 20010223
Integration Core Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. 39(51) 15775-15782 Eui-Jun Jeong, Geum-Sook Hwang, Kyung Hee Kim, Min Jung Kim, Sunghoon Kim, Key-Sun Kim Biochemistry 20001226
Integration Core Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. 275(41) 31682-31688 Jeongwoo Kang, Taeho Kim, Young-Gyu Ko, Seung Bae Rho, Sang Gyu Park, Min Jung Kim, Ho Jeong Kwon, Sunghoon Kim The Journal of biological chemistry 20001013
Integration Core A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases. 275(35) 27062-27068 Youngsoo Kim, Joongchul Shin, Rongbao Li, Chaejoon Cheong, Kyounghee Kim, Sunghoon Kim The Journal of biological chemistry 20000901
Integration Core An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. 28(15) 2866-2872 Jee Eun Kim, Kyoung-Hee Kim, Sang Won Lee, Wongi Seol, Kiyotaka Shiba, Sunghoon Kim Nucleic Acids Research 20000801
Integration Core Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex. 275(28) 21768-21772 Taeho Kim, Sang Gyu Park, Jee Eun Kim, Wongi Seol, Young-Gyu Ko, Sunghoon Kim The Journal of biological chemistry 20000714
Integration Core Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. 149(3) 567-574 Young Gyu Ko, Young-Sun Kang, Eun-Kyoung Kim, Sang Gyu Park, Sunghoon Kim The Journal of Cell Biology 20000501
Integration Core Death effector domain of a mammalian apoptosis mediator, FADD, induces bacterial cell death. 35(6) 1540-1549 Sang Won Lee, Young Gyu Ko, SookHee Bang, Key-Sun Kim, Sunghoon Kim Molecular Microbiology 20000301
Integration Core Methionine analogue probes functionally important residues in active site of methionyl-tRNA synthetase. 32(6) 547-553 Young Joon Jo, Sang Won Lee, Myung Kyun Jo, Jee Woo Lee, Mee-Kyoung Kang, Jeong Hyeok Yoon, Sunghoon Kim BMB Reports (Journal of Biochemistry and Molecular Biology) 19991101
Integration Core Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. 274(24) 16673-16676 Sang Gyu Park, Keum Hee Jung, Jong Sang Lee, Yeong Joon Jo, Hiromi Motegi, Sunghoon Kim, Kiyataka Shiba. The Journal of Biological Chemistry 19990611
Integration Core Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase. 9(10) 1365–1370 Jeewoo Lee, Sang Uk Kang, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kkwak, Sunghoon Kim Bioorganic & Medicinal Chemistry Letters 19990517
Integration Core Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex. 96(8) 4488-4493 Seung Bae Rho, Min Jung Kim, Jong Sang Lee, Wongi Seol, Hiromi Motegi, Sunghoon Kim, Kiyotaka Shiba Proceedings of the National Academy of Sciences of the United States of America 19990413
Integration Core Methionine analogues as inhibitors of methionyl-tRNA synthetase. 8(24) 3511-3514 Jeewoo Lee, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kwak, Sunghoon Kim Bioorganic Medicinal Chemistry Letters 19981215
Integration Core Cloning and characterization of mitochondrial methionyl-tRNA synthetase from a pathogenic fungi Candida albicans. 215(2) 311-318 Sang Won Lee, Yeong Joon Jo, Sunghoon Kim Gene 19980730
Integration Core Biochemical and phylogenetic analyses of methionyl-tRNA synthetase isolated from a pathogenic microorganism, Mycobacterium tuberculosis. 427(2) 259-262 Sunghoon Kim, Yeong Joon Jo, Sang Ho Lee, Hiromi Motegi, Kiyataka Shiba, Mandana Sassanfar and Susan A. Martinis FEBS Letters 19980508
Integration Core A multifunctional repeated motif is present in human bifunctional tRNA synthetase. 273(18) 11267-11273 Seung Bae Rho, Jong Sang Lee, Eui Jun Jeong, Key Sun Kim, Yang Gyun Kim, Sunghoon Kim The Journal of biological chemistry 19980501
Integration Core Abnormal proteins enhance stress-induced cell death. 243(1) 153-157 Se Jin Kim, Sunghoon Kim Biochemistry & Biophysical Research Communications 19980204

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